What Is Zosyn?
Zosyn is a combination medication that contains two drugs, piperacillin and tazobactam.
Piperacillin is an antibiotic, and tazobactam is a beta-lactamase inhibitor, which prevents resistance to the antibiotic.
Zosyn is used to treat a variety of bacterial infections, including pneumonia, appendicitis, E. coli, pelvic inflammatory disease, and postpartum endometritis.
Zosyn can treat a bacterial infection, but it won't help viral infections, such as the flu or the common cold.
The medicine is typically added to an intravenous fluid drip in a healthcare facility, and is sometimes given along with other antibiotics. It's not available as an oral pill or capsule.
The Federal Drug Administration (FDA) first approved Zosyn in 1993.
Before taking Zosyn, you should tell you doctor if you have or have ever had:
It's important that the drug be administered exactly as your doctor prescribes. Don't stop treatment on your own, as this could worsen your infection.
Skipping doses of Zosyn may also increase your risk of further infection that is resistant to antibiotics.
A hypersensitivity reaction to this drug is serious and potentially even fatal. It's extremely important to alert your physician if you are allergic to any of the following medications before being given Zosyn:
Also, tell your health care provider if you are on a low-salt diet before taking this drug.
It's important to keep all appointments with your doctor while on Zosyn, since important tests may be necessary to measure your response to the drug.
Pregnancy and Zosyn
Zosyn is a Pregnancy Category B drug, which means it's not likely to harm an unborn baby. You should talk to your doctor before being given this medicine while pregnant.
The drug can pass into breast milk and may harm a breastfeeding baby. You should tell your doctor before breastfeeding while being given Zosyn.
Zosyn Side Effects
Common Side Effects of Zosyn
You should tell your doctor if any of the following side effects become severe or don't go away:
Serious Side Effects of Zosyn
You should alert your doctor right away if you experience any of the following serious side effects:
- Itchy skin
- Shortness of breath
- Unusual bleeding or bruising
- Diarrhea that's watery or bloody
- Fever, chills, body aches, or other flu symptoms
- Rapid heart rate
You should always tell your doctor about any prescription, non-prescription, illegal, and recreational drugs; herbal remedies; and nutritional and dietary supplements you're taking, especially the antibiotics listed in the Warnings section or the following medications:
Zosyn and Other Interactions
You should tell your doctor and laboratory personnel you are taking Zosyn before having any medical tests. This medication may interfere with certain tests and can cause unusual results.
Zosyn is typically given three to four times a day (or once every 6 hours) over 30 minutes through an IV solution that drips through a needle or catheter in the vein or is infused by a pump. Zosyn is usually given for 7 to 10 days.
If you are receiving an IV infusion at home and are instructed to administer Zosyn yourself, you or your caregiver should do the following:
- Follow all directions on your prescription label carefully.
- Check that the Zosyn solution is clear and free of floating particles before administering it.
- Don't use the solution if it's discolored or contains particles or if the bag of solution has a leak.
- Administer Zosyn slowly, usually over a 30-minute period.
- Use a disposable needle only once. Discard the needle in a puncture-proof container that's kept out of the reach of children and pets.
Symptoms of a Zosyn overdose include the following:
If you suspect an overdose, alert the healthcare professional in charge of your care or, if you are not in the hospital, contact a poison control center or emergency room immediately.
You can get in touch with a poison control center at (800) 222-1222.
Missed Dose of Zosyn
If you miss a dose of Zosyn, take it as soon as you remember.
However, if it's almost time for you next scheduled dose, skip the missed dose. Don't take extra medicine to make up for a missed dose.
Video: How to mix Zosyn, step-by-step
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